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Rapid Mixer Granulator - RMG /High Shear Mixer Granulator-HSMG (High Performance Mixing and Wet Granulation Process Technic) Application & Process : • The High Shear Mixer Granulator used for process of fast dry & wet mixing, homogenizing, humidifying and granulating of the powder in Pharmaceutical, Chemical, Cosmetic, Food, Plastic, General Mixing Industries. • High Shear Mixer Granulator series is characterized by the compact construction, modern design and all the user and maintenance friendly attributes which form the ergonomics design aspects are essential for a wide range of application. • The High Shear Mixer Granulator performs dry mixing & wet granulating by basic design of the special four arm of the mixing impeller and sequences of the mixing process in the cylindrical mixing drum with rounded connection to the base plate, achieve another special effect. The mixing process runs without varying pressure zone in the volume of mixing product. Separately driven multiple choppers can effectively intensify the mixing result in particular when liquid or paste components are added. During humidifying and granulating process of the products the chopper controls and regulates the granular spectrum and structure of the granules according to the product, chopper shape and time. The HSMG system requires only small quantities of granulating liquid or pastes to obtain the required granulate structure. This reduces the amount of drying energy required. Salient Features : • High speed mixing & granulating • Design is cGMP - Current Good Manufacturing Practices compliance • All Product contact parts AISI 316 & non contact parts AISI 304. • Automated maxing and granulating process in single bowl. • High Precision mixing and granulation with Short Batch Time, Problem free Cleaning and Residue Free Discharge. • Unique design with four arm mixing impeller with blade angle to pushing product radically outward. • Chopper blade designed to cuts lumps and make granules. • Dual speed mixing impeller for mixing and intensify chopper for granulating. • Flush fitting discharge plug is electro pneumatically operated. • Air pursing for seal for both shafts. Optional Features : • PLC Controls with HMI touch screen, • Inline Milling at discharge, • Variable speed drive for main impeller and chopper. • Product bowl Jacketing for heating/ cooling and vacuumized mixing process. • Binder adding by spraying system with peristaltic pump. • Material charging by bin loader with IBC. • Flame proof motor and electrical. Safety Features : • Total drive transmission system enclosed • Limit switch installed in the top lid ensure lid is closed • Air pressure switch installed to ensure pressure is in limit. • Limit switch installed at discharge to ensure product container underneath of discharge. • Overload relay Protection and Emergency stop button
Liquid Syrup Manufacturing Process (Preparation Vessel & Liquid Syrup Manufacturing Plant)  Application & Process : Prism has been designed & manufacturing preparation vessels and has consolidated a process knowledge concerning sterile injectable solution, dispersions, ophthalmic products, syrup and suppositories.  Preparation Vessels & Tank : • Extremely hygienic processing. • Least manual handling. • Design compliance with cGMP • Capacity up to 10, 000 Liter. • Product Contact AISI 316L • Atmospheric, Vacuum or Pressure Operation. • Jacket for heating & cooling. • Vessel Inside Pressure (-1 /+2 Bar) • Heating Jacket Pressure (-1 /+6 bar) • Heating by steam or hot water circulation. • Thermal Insulated. • Mechanicals or Electro polishing of internal surface. • Welded, flanged or hinged type cover • Integrated Cleaning in Place-CIP. • Sterilizing In Place-SIP as an Option. • Portable execution on request. • Validation protocols & Instrumentation celebration.  Variable Speed Agitation : • Agitator can be top or bottom driven or magnetically driven. • Propeller type, Anchor type provided with High speed disperser or rotor-stator homogenizer. • Single or double mechanical seal.  Fully automatic Liquid Syrup Manufacturing Plant consisting of : • Sugar Charging / Transfer System. • Sugar Melting Vessel with mixing stirrer. • Basket Filter & Transfer Pump. • Syrup Manufacturing Vessel with stirrer. • Inline Homogenizer. • Zero Hold up Filter press. • Storage Tank with stirrer. • Interconnecting pipeline. • Transfer Pumps. • Integrated automatic control panel. • Working Platform.  Turn Key Process Line : • For production, filtration, transfer and storage solution. • Pre reparation vessels. • Inline homogenizer. • Inter Connecting Pipe • Solid or sugar Charging System • Working Platform.  Automation available, appropriate for the intended process function, including CIP and SIP : • Controls of all function by PLC Controls with HMI Touch screen. • Level controls by means of capacitance probe or electronic load cells. • Digital indication and controls of all process parameters for Process time, agitator speed, temperature, pressure & level.
The Prism Pharma Machinery is having world's largest range for process equipments. The company is known for innovative manufacturer for processing system for drying, granulating, mixing, milling, size reducing, blending, tabletting, coating, pelletizing, pellet coating, stirring, homogenizing, Vacuumised mixing, filtration, evaporation, containment, material conveying, cleaning and fermentation as well as process integration and process automation service. Prism focuses on specialized mechanical engineering, especially process engineering and equipment along with automation engineering.
(Roll Compactor - Dry Compaction) Powder Dry Granulation Process. Application & Process : The Roll Compactor machine is used for increased bulk density, making granules, dust free processing and reducing particle size of pharmaceutical ingredients in pharmaceutical industry, in food as well as chemical industry for densification and granulation of powder. The material in form of powder passes through the two counter rotating rolls of roller compactor under very high pressure. As the volume decreases through the region of maximum pressure, the material is formed into a solid compact sheet or flakes of ingredients. These flakes or compact sheet of ingredients are reduced in size to obtain the desired grain size. The machine takes extra care to prevent the generation of fine during this process. New Design Features : • Design is cGMP - Current Good Manufacturing Practices compliance • All Product contact parts AISI 316 & non contact parts AISI 304. • To achieve maximum bulk density and output by various type of rolls. • Available different type of rolls - 1. Plain 2.Corrugated 3.Knurled. • Machine fitted with Corrugated rolls. • Option available for Hydraulically operated Uniform force distribution system can be provided for produce granules equal quality • Option available for the compacting roll can be designed to provide with water cooling system.. • A C Frequency Variable Speed Drive for Auger • Top and bottom scrapper of the roll to scrape off powder sticking on the roll. • Enclosed drive with heavy duty gear box and motor for roll and auger/ feeder. • The hopper and auger/ feeder assembly is lifted by hydraulically for easy cleaning & dismantling. Optional Features : • Option for Uniform force system by hydraulically for Roller. • Optional Water Cooling system for rolls & hopper. • Inline Granulation with Granulator & sifting • PLC Controls with HMI touch screen. • Automatic loading by Vacuum Transfer system. • Flame Proof Electrical. • AC frequency drive for Roller. Safety Features : • Limit switch for chamber, Slip clutch at drive of auger. • Overload relay & Emergency stop.
Ointment - Cream - Tooth Paste- Gel Manufacturing Plant Semi solid manufacturing Plants are ideal tools for the pharmaceutical & cosmetic industries for the production of Ointment, Cream, Lotion, Gel, Tooth Paste & emulsions & homogenization. Application & Process: Ointment manufacturing Plants are ideal tools for the pharmaceutical & cosmetic industries for the production of Ointment, Cream, Lotions, Tooth Paste & other emulsions & homogenization. In operation, • The pre determined water quantity is added to water heating vessel. The steam is supplied and the addition of additives manually and mix at the set temperature. • Then the oil, wax, petroleum jelly is charged to wax phase vessel. The steam and heat are supplied in manufacturing vessel and the additives are added manually and mixed at the set temperature. • Vacuum pump transfers the heated wax and heated water to main manufacturing vessel. The additives are added manually and mixed at the set temperature and also the homogenizer performs emulsification and dispersion • After confirmation of cream / ointment discharge the product is transferred to storage tank using lobe pump. • Keeping the product under slow speed agitation in storage vessel the product is transferred to ointment tube filling machine through ointment transfer pump. Fully automatic Ointment, Cream, Tooth Paste , Gel manufacturing plant consisting of  Pre determined water phase vessel.  Pre determined oil, wax, petroleum jelly phase vessel.  Vacuum Homogenizer Mixer vessel.  Vacuum Pump  Storage vessel  Interconnecting pipeline.  Transfer Pumps (Bump Pump, Lobe Pump & Metering pumps)  Integrated automatic control panel.  Working Platform Design Features :  Design compliance with cGMP • Integrated Cleaning in Place-CIP. • Sterilizing In Place-SIP as an Option.  Batch Size • Available model 50 Liter to 5000 Liter working Capacity.  Materials • Product Contact AISI 316L. • Food Grade silicon rubber for seal.  Water Phase Vessel • Jacket for heating & cooling. • Heating Jacket Pressure (4 bar). • Heating by steam or hot water circulation. • Propeller stirring with top mounting. • Temperature controller & safety pressure Valve. • Bottom discharge with valve.  Wax Phase Vessel • Jacket for heating & cooling. • Heating Jacket Pressure (4 bar). • Heating by steam or hot water circulation. • Propeller stirring with top mounting. • Temperature controller & safety pressure Valve. • Bottom discharge with valve.  Manufacturing Vacuumize Homogenizer Vessel. • Jacket for heating & cooling. • Vacuumize process. • Vessel Inside Pressure (-1 /+2 Bar) • Heating Jacket Pressure (-1 /+6 bar) • Heating by steam or hot water circulation. • Agitator mixer with self pressure Teflon scrapper. • Scrapper cleanly working on both side. • High speed Homogenizer with toothed Rotor - stator type. • RPM sleeplessly with variable speed drive for agitator & Homogenizer. • High shear & pressurization of the homogenizer. • Thus homogenization of high viscosities up to 400.000 mPas. • Homogenizer mounted on lower position in the centre of vessel. • Top lid with motorized top lid for lifting & lowering. • Safety Interlock process with limit switch. • Connection for Vacuum, Charging, Eye glass window, Light glass, CIP, SIP, Pressure gauge & safety valve. • Temperature controller & safety pressure Valve. • Bottom discharge with valve.  Vacuum System • Water Ring Vacuum Pump. • Vacuum gauge & Vacuum relief valve.  Storage Vessel • Skid type storage vessel. • Bottom cone is Jacket for heating.  Inter Connecting Pipe • Inter connecting Pipe line of all vessel for transfer Water, Wax & products. • Recirculation in manufacturing vessels. • Vacuum connecting pipe.  Working Platform • Rigid structure with anti slipping embossed plat. • Made from AISI 304.  Controls & Visualization • Electric Controls with digital display. • Optional PLC Controls with HMI Touch screen. • RPM and Process time entries. • Temperature controls- Heat/cool. • Vacuum start- Stop. • Integrated Data Recording for batch.  Safety Features • Emergency stop button • Safety vacuum relief valve & Indicator Gauge. • Safety Pressure Valve. • Limit switch at top lid
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