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Ointment - Cream - Tooth Paste- Gel Manufacturing Plant Semi solid manufacturing Plants are ideal tools for the pharmaceutical & cosmetic industries for the production of Ointment, Cream, Lotion, Gel, Tooth Paste & emulsions & homogenization. Application & Process: Ointment manufacturing Plants are ideal tools for the pharmaceutical & cosmetic industries for the production of Ointment, Cream, Lotions, Tooth Paste & other emulsions & homogenization. In operation, • The pre determined water quantity is added to water heating vessel. The steam is supplied and the addition of additives manually and mix at the set temperature. • Then the oil, wax, petroleum jelly is charged to wax phase vessel. The steam and heat are supplied in manufacturing vessel and the additives are added manually and mixed at the set temperature. • Vacuum pump transfers the heated wax and heated water to main manufacturing vessel. The additives are added manually and mixed at the set temperature and also the homogenizer performs emulsification and dispersion • After confirmation of cream / ointment discharge the product is transferred to storage tank using lobe pump. • Keeping the product under slow speed agitation in storage vessel the product is transferred to ointment tube filling machine through ointment transfer pump. Fully automatic Ointment, Cream, Tooth Paste , Gel manufacturing plant consisting of  Pre determined water phase vessel.  Pre determined oil, wax, petroleum jelly phase vessel.  Vacuum Homogenizer Mixer vessel.  Vacuum Pump  Storage vessel  Interconnecting pipeline.  Transfer Pumps (Bump Pump, Lobe Pump & Metering pumps)  Integrated automatic control panel.  Working Platform Design Features :  Design compliance with cGMP • Integrated Cleaning in Place-CIP. • Sterilizing In Place-SIP as an Option.  Batch Size • Available model 50 Liter to 5000 Liter working Capacity.  Materials • Product Contact AISI 316L. • Food Grade silicon rubber for seal.  Water Phase Vessel • Jacket for heating & cooling. • Heating Jacket Pressure (4 bar). • Heating by steam or hot water circulation. • Propeller stirring with top mounting. • Temperature controller & safety pressure Valve. • Bottom discharge with valve.  Wax Phase Vessel • Jacket for heating & cooling. • Heating Jacket Pressure (4 bar). • Heating by steam or hot water circulation. • Propeller stirring with top mounting. • Temperature controller & safety pressure Valve. • Bottom discharge with valve.  Manufacturing Vacuumize Homogenizer Vessel. • Jacket for heating & cooling. • Vacuumize process. • Vessel Inside Pressure (-1 /+2 Bar) • Heating Jacket Pressure (-1 /+6 bar) • Heating by steam or hot water circulation. • Agitator mixer with self pressure Teflon scrapper. • Scrapper cleanly working on both side. • High speed Homogenizer with toothed Rotor - stator type. • RPM sleeplessly with variable speed drive for agitator & Homogenizer. • High shear & pressurization of the homogenizer. • Thus homogenization of high viscosities up to 400.000 mPas. • Homogenizer mounted on lower position in the centre of vessel. • Top lid with motorized top lid for lifting & lowering. • Safety Interlock process with limit switch. • Connection for Vacuum, Charging, Eye glass window, Light glass, CIP, SIP, Pressure gauge & safety valve. • Temperature controller & safety pressure Valve. • Bottom discharge with valve.  Vacuum System • Water Ring Vacuum Pump. • Vacuum gauge & Vacuum relief valve.  Storage Vessel • Skid type storage vessel. • Bottom cone is Jacket for heating.  Inter Connecting Pipe • Inter connecting Pipe line of all vessel for transfer Water, Wax & products. • Recirculation in manufacturing vessels. • Vacuum connecting pipe.  Working Platform • Rigid structure with anti slipping embossed plat. • Made from AISI 304.  Controls & Visualization • Electric Controls with digital display. • Optional PLC Controls with HMI Touch screen. • RPM and Process time entries. • Temperature controls- Heat/cool. • Vacuum start- Stop. • Integrated Data Recording for batch.  Safety Features • Emergency stop button • Safety vacuum relief valve & Indicator Gauge. • Safety Pressure Valve. • Limit switch at top lid
Liquid Syrup Manufacturing Process (Preparation Vessel & Liquid Syrup Manufacturing Plant)  Application & Process : Prism has been designed & manufacturing preparation vessels and has consolidated a process knowledge concerning sterile injectable solution, dispersions, ophthalmic products, syrup and suppositories.  Preparation Vessels & Tank : • Extremely hygienic processing. • Least manual handling. • Design compliance with cGMP • Capacity up to 10, 000 Liter. • Product Contact AISI 316L • Atmospheric, Vacuum or Pressure Operation. • Jacket for heating & cooling. • Vessel Inside Pressure (-1 /+2 Bar) • Heating Jacket Pressure (-1 /+6 bar) • Heating by steam or hot water circulation. • Thermal Insulated. • Mechanicals or Electro polishing of internal surface. • Welded, flanged or hinged type cover • Integrated Cleaning in Place-CIP. • Sterilizing In Place-SIP as an Option. • Portable execution on request. • Validation protocols & Instrumentation celebration.  Variable Speed Agitation : • Agitator can be top or bottom driven or magnetically driven. • Propeller type, Anchor type provided with High speed disperser or rotor-stator homogenizer. • Single or double mechanical seal.  Fully automatic Liquid Syrup Manufacturing Plant consisting of : • Sugar Charging / Transfer System. • Sugar Melting Vessel with mixing stirrer. • Basket Filter & Transfer Pump. • Syrup Manufacturing Vessel with stirrer. • Inline Homogenizer. • Zero Hold up Filter press. • Storage Tank with stirrer. • Interconnecting pipeline. • Transfer Pumps. • Integrated automatic control panel. • Working Platform.  Turn Key Process Line : • For production, filtration, transfer and storage solution. • Pre reparation vessels. • Inline homogenizer. • Inter Connecting Pipe • Solid or sugar Charging System • Working Platform.  Automation available, appropriate for the intended process function, including CIP and SIP : • Controls of all function by PLC Controls with HMI Touch screen. • Level controls by means of capacitance probe or electronic load cells. • Digital indication and controls of all process parameters for Process time, agitator speed, temperature, pressure & level.
Twin Cabinate Bin Washing System : CIP / WIP Closed Clean In Place / Wash in Place System for IBC Bin  Prism Pharma Machinery is pleased to announce our new Machine Development 'Twin Cabinate Bin Washing System' for AUROBINDO APL Healthcare Limited - India.  CIP/ WIP system is useful for cleaning and washing of IBC Bin for inner and outer washing and drying automatically.  Application & Process: • Automatic washing station is consists of closed washing cabinet, washing system with pump, Hot air handling system and PLC controls system with HMI. • Used bin is oriented in the closed cabinet and closed entrance main door for washing. Washing cycle time can be set as per requirements for Plain water, Hot water, Detergent, Distilled water. In auto mode wash cycle works as per set parameter in PLC system. There are nos. of spraying nozzle for washing at all corners & all side walls for outer washing. Top mounting spraying nozzle is fitted with telescopic pneumatic cylinder to wash inner surface of the bin, Inner washing nozzle move upward & downward during washing for completely washing of bin. The cabinet is having drain pot with recirculation of water connection with pump if required then it can be re circulated. After complete washing cycles then bin is dry by passed filter hot air circulation by air handling unit. After drying of Bin on set temperature then released for new batch safe storage. • Closed CIP Bin washing system will be provided with hot water genrator-500 liter, Detergent tank 50lIter, Hot air AHU system, Closed washing cabinet and PLC Controls system with pressure pump and connection for PW and WFI water.  IBC Bin Washing system futures: • Designed as per cGMP principles followed at pharmaceutical corporations globally. • All contact parts AISI 316 & non contact parts AISI 304. • 2 Nos. Closed cabinet type washing system for washing of Bin with water skid, hot air AHU. • 1 No washing booth for vessel and 1 No. washing booth for tray. • WIP & CIP (Wash & Cleaning-In-Place) is a system designed for automatic cleaning by Portable water, Hot Water, detergent, WFI and rinse solutions without major disassembly and assembly work • PLC programmed and automated with interlocks and standard pharma safety procedures. • Principle of high pressure and low volume of water for Washing results in less water consumption and low effluent quantity • The cleaning can be carried out with automated systems is a reliable process that meets the stringent hygiene regulations • Design is completely customizable depending on specific client constraints and requirements • Powerful jets ensure complete internal and external washing of the IBC. • Design optimized to reduce consumption of water and energy. • Specific wash zones for bottom valves and lids. • Telescopic spraying nozzle for inside washing of IBC. • Telescopic hood provides with pneumatic operated for hot air flow inside of the IBC. • One step setting of washing and drying operation. • Water skid Systems can be provided reservoirs for detergent and rinse solutions as well as pumping. • Hot air drying skid- AHU with Double Scan AHU with inside s.s.304 24SWG. And outside powder coated with Pre filter- 10 & 5 micron, Blower-2 hp, heating coil- steam, HEPA 0.3 micron filter. • The washing process consists of several cycles in which rinsing material is recycled through the bin, pumps, valves and other process equipment in the flow system. • All the operation processes take place in sealed pipe line, which is easy to operate saving work and meets high sanitary requirement. • It has advantages as energy-saving, high work efficiency, perfect cleaning effect, operator safety and easy to operate and maintain. • The booth has a provision of locating a single IBC at a time for washing & drying. • Double door design for inlet of IBC Bin and outlet of Bin. • The services such as filtered potable water, hot water, dm / purified water and steam to be provided near the system in the technical area above/next to the machine. • The system is located in-between the unclean & clean wash area as shown above. • The machine has integrated drain pan. • All the services and technical area equipment is located in the booth or on a floor above. The necessary piping & ducting is routed down from openings in the slab. • Flow Rate controls for PW and WFI. • Pressure display for PW, WFI, water for jet and compressed air. • Advance PLC controls with Industrial PC -Touch screen controls with SCADA for records, recipe management and interactive commands. • Swing doors provide convenient loading and removal of bins • Full height glass doors provide complete process monitoring. • Single step operation Load Soiled IBC and 20 to 25 minutes later Remove Washed and dried IBC. • Sample pot at drain. • Option for Hot water generator vessel with temperature controller.
Tablet Press Machine - TabXpress-IV High Speed Double Sided with Pre-Compression Tablet Press Machine- GMP Model  Application & Process : • Prism TabXpress-IV is a High Speed Double Sided Rotary Tablet Compression Press suitable for millennium batch size production. • TabXpress-IV designed in an effort to exceed the highest cGMP requirement and to ensure the most economical and efficient tablet production. The TabXpress -IV features a unique ergonomic design for EASY to Operate, EASY to Fast Changeover, EASY to Clean with minimum down time. The TabXpress is completely separated into three zones i.e. Tablet Compression zone, Machine service zone and Electrical controls zone. The Optional feature of TabXpress-IV machine can provide with Touch Screen Operate Interface with PLC Controls, which is mounted in a separate electric controls cabinet. • The TabXpress-IV Tablet Press is offered in four different models viz. Tooling 45 Stn "D" Type, 55 Stn "B" Type, 69 Stn "BB" Type, 75 Stn "BB" Type. • The Machine Ergonomics Design Concept : • The TabXpress-IV has been completely new designed according to the most modern ergonomic aspects. • cGMP confirm. • Machine's basic construction with separate compression zone and drive zone and electric controls zone. • Fast Cleaning and Changeover capability. • Stainless Steel and Acrylic Glass Surrounding. • Easy to Operate and Maintenance.  Salient Features : • Design Conforming to cGMP standards. • Contact parts SS 316 and non contact parts SS 304. • TabXpress-IV is high speed double sided tablet press with internal gear drive, pre compression and suitable for medium size batch production and offered in three model "D" , "B" & "BB" Tooling • Simple and Convenient Operation, Changeover, Cleanliness, Operator Protection and Easy to Maintenance. • Pre-Compression System to improve tablet quality • All Controls like tablet thickness, weight adjustment, Pre-press adjustment are in front of the machine and outside the compression zone • Turret Drive from Closed Gearbox through Internal Helical Gearing with Continuous Lubrication. • Electro Magnetic Clutch Drive for Safety, Ease and Maintains Free operation. • A C Frequency drive for Turret Motor and Feeder Motor. • Force Feeder for Powder Feeding with Bottom side drive. • Fast changeover and Easy cleaning designed with Easy removal Weight adjustment sector. • Upper guard with Hydraulic Cylinder and Lower guard From S.S. 304 fitted Limit switch. • Turret made from Special graded casting and option for 3pc.turret with S.S.316 Diepot. • Hydraulic Power Pack for Pressure Loading & Overloading release. • Auto Lubrication System for Turret gearing and fulcrum pins. • Paint free Tablet Compression zone. • Dust suction nozzle for Controlling Dusting. • Closed Dust free Front Electric Control Panel easy Removal type  Optional Features : • Gravity feeder System. • Powder level sensor in hopper. • During Start and Stop Rejection and Sampling device • Advance PLC controls with Touch Screen interface..  Safety Features : • Interlocked upper guard and Overload relay protection. • Overload pressure release mechanism. • Emergency stop button.
Rapid Mixer Granulator - RMG /High Shear Mixer Granulator-HSMG (High Performance Mixing and Wet Granulation Process Technic) Application & Process : • The High Shear Mixer Granulator used for process of fast dry & wet mixing, homogenizing, humidifying and granulating of the powder in Pharmaceutical, Chemical, Cosmetic, Food, Plastic, General Mixing Industries. • High Shear Mixer Granulator series is characterized by the compact construction, modern design and all the user and maintenance friendly attributes which form the ergonomics design aspects are essential for a wide range of application. • The High Shear Mixer Granulator performs dry mixing & wet granulating by basic design of the special four arm of the mixing impeller and sequences of the mixing process in the cylindrical mixing drum with rounded connection to the base plate, achieve another special effect. The mixing process runs without varying pressure zone in the volume of mixing product. Separately driven multiple choppers can effectively intensify the mixing result in particular when liquid or paste components are added. During humidifying and granulating process of the products the chopper controls and regulates the granular spectrum and structure of the granules according to the product, chopper shape and time. The HSMG system requires only small quantities of granulating liquid or pastes to obtain the required granulate structure. This reduces the amount of drying energy required. Salient Features : • High speed mixing & granulating • Design is cGMP - Current Good Manufacturing Practices compliance • All Product contact parts AISI 316 & non contact parts AISI 304. • Automated maxing and granulating process in single bowl. • High Precision mixing and granulation with Short Batch Time, Problem free Cleaning and Residue Free Discharge. • Unique design with four arm mixing impeller with blade angle to pushing product radically outward. • Chopper blade designed to cuts lumps and make granules. • Dual speed mixing impeller for mixing and intensify chopper for granulating. • Flush fitting discharge plug is electro pneumatically operated. • Air pursing for seal for both shafts. Optional Features : • PLC Controls with HMI touch screen, • Inline Milling at discharge, • Variable speed drive for main impeller and chopper. • Product bowl Jacketing for heating/ cooling and vacuumized mixing process. • Binder adding by spraying system with peristaltic pump. • Material charging by bin loader with IBC. • Flame proof motor and electrical. Safety Features : • Total drive transmission system enclosed • Limit switch installed in the top lid ensure lid is closed • Air pressure switch installed to ensure pressure is in limit. • Limit switch installed at discharge to ensure product container underneath of discharge. • Overload relay Protection and Emergency stop button
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